Peptide Cyclization and Cyclodimerization by CuI-Mediated Azide−Alkyne Cycloaddition
نویسندگان
چکیده
منابع مشابه
Peptide cyclization and cyclodimerization by Cu(I)-mediated azide-alkyne cycloaddition.
Head-to-tail cyclodimerization of resin-bound oligopeptides bearing azide and alkyne groups occurs readily by 1,3-dipolar cycloaddition upon treatment with Cu(I). The process was found to be independent of peptide sequence, sensitive to the proximity of the alkyne to the resin, sensitive to solvent composition, facile for alpha- and beta-peptides but not for gamma-peptides, and inhibited by the...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2009
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo802097m